Endocrine Abstracts

The thyroid hormone (TH) transporters Mct8 (encoded by Slc16a2) and Oatp1c1 (encoded by Slco1c1) are critically involved in mediating TH passage across mouse brain barrier cells. Mct8/Oatp1c1 deficient mice (= DKO mice) exhibit a strongly reduced brain TH content and consequently, an impaired neuronal development and hypomyelination all of which are also seen in patients with MCT8 deficiency (Allan-Herndon-Dudley Syndrome, AHDS). Our recent studies of mouse mutants lacking bot...